Puka Nacua, Justin Jefferson, And More

BALTIMORE, MARYLAND – OCTOBER 12: Puka Nacua #12 of the Los Angeles Rams reacts after running with the ball during an NFL football game against the Baltimore Ravens at M&T Bank Stadium on October 12, 2025 in Baltimore, Maryland. (Photo by Michael Owens/Getty Images)

Getty Images

There has been no easing of injuries across the NFL. The latest big name to be lost for the season is De’Von Achane, who suffered a torn ACL last week for the Dolphins. There are several other impactful injuries at various positions, so let’s highlight some of them and decide what action to take in fantasy football. For those who need reinforcements, check out our Week 4 waiver wire targets.